This website is intended for Healthcare Professionals outside of the UK and US.

Dic Cover Desktop

Disseminated intravascular coagulation in neonates

Disseminated intravascular coagulation (DIC) is one of the causes of high mortality in severe neonatal diseases. The trigger mechanisms of neonatal DIC syndrome are known to be:1

Severe hypoxia


Surgical intervention



This is further reinforced by the definition given by the International Society of Thrombosis and Haemostasis (ISTH) to DIC, which states:2

“Disseminated intravascular coagulation is a syndrome characterized by the systemic activation of blood coagulation, which generates intravascular fibrin, leading to thrombosis of small and medium-sized vessels, and eventually organ dysfunction.”2

Furthermore, DIC rarely occurs without an underlying illness. However, in children, homozygous Protein C (PC) deficiency can lead to severe neonatal Purpura Fulminans (PF) due to low PC levels, without an underlying illness. Heterozygosity and homozygosity for PC deficiency, therefore, can also be considered a risk factor for DIC.3

The haemostatic system in neonates significantly differs from children and adults and leaves them vulnerable to DIC compared to the latter.4 Given the significant differences in the value of coagulation factors between children and adults, it is important to understand the development of haemostasis and interpret the results with caution.4


Learn more about the severity classification of SCPCD


  1. Ivanov D, et al. The specific characteristics of DIC syndrome vary with different clinical settings in the newborn. J Matern Fetal Neonatal Med. 2014;27:1088-1092.

  2. Wada H, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013;11:761-767.

  3. Sommeijer DW, Reitsma PH. Genetic Risk Factors for Disseminated Intravascular Coagulation. Madame Curie Bioscience Database [Internet]. Austin, TX: Landes Bioscience; 2000-2013. [Last accessed May 2018].

  4. Rajagopal R, et al. Disseminated intravascular coagulation in paediatrics. Arch Dis Child. 2017;102(2):187-193.


Interested in severe congenital protein c
Deficiency (SCPCD) and its management ?
Sign up below !

Sorry! There are some errors below that need to be fixed.
There seems to have been an error when sending the form.

You have the right to opt out of receiving such electronic communications and/or our newsletter, at any time, by using the opt out link in the communication or by contacting us at For more information on how Takeda processes your personal data, please refer to our Privacy Notice

Please include @ in your email adress


Thank you for submitting your details

You are about to leave this website. Takeda has no influence or control over the content of this third party website.
Continue Cancel
This website is intended for Healthcare Professionals outside of the US and the UK. The website has been developed by Takeda in accordance with industry and legal standards. Takeda makes every reasonable effort to include accurate and current information. However, the information provided on the website is not exhaustive.
Please tick the boxes to enter the site

Yes, I am a healthcare professional outside of the US and UK


No, I am not a healthcare professional outside of the US and UK