Epidemiology of SCPCD
Incidence and prevalence
Severe Congenital Protein C (PC) Deficiency is a rare, autosomal recessive disorder,1 and estimates of its incidence and prevalence vary.
The predicted prevalence of SCPCD is low, ranging from 1 in 40,000 to 250,000 people.3
Potential explanations for the low number of identified individuals include high fœtal mortality, death before diagnosis, under-diagnosis and under-reporting.1,3
Consanguinity, highly prevalent in the Middle East, Northern Africa and South and Western Asia,4 seems to play an important role in the incidence of SCPCD. Children born of consanguineous parents have a significantly higher risk of developing some genetic diseases compared with children born of non-consanguineous unions.5,6 Parental consanguinity is a common factor associated with people suffering from SCPCD.1
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