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Severity Cover Desktop

Severity Classification

Protein C deficiency severity is determined by the remaining
Protein C activity level

Mean protein C (PC) levels in healthy individuals1

10.scpcd Desktop Severity Maquette 1250Px

The severity of PC deficiency is determined by the remaining PC activity level. In healthy individuals, PC levels increase with age, with activity levels of 65–135 IU/dL considered to be normal for an adult.1

 

pc levels AND SEVERITY OF PC DEFICIENCY1

According to Goldenberg et al., adults with PC activity levels between 20 and 65 IU/dL are regarded as having mild PC deficiency, while moderately severe PC deficiency occurs when activity is between 1 and 20 IU/dL.1

Severe deficiency is defined by PC activity lower than 1 IU/dL.1 People with congenital PC deficiency caused by homozygous or compound heterozygous mutations have severe deficiency (SCPCD), whereas those with heterozygous mutations tend to have mild/moderate PC deficiency,1,2 with plasma PC activity being about half of the normal level of activity.3

Learn more about which tests can help confirm SCPCD

Protein C Activity Level (IU/dL)1*
Severity
65-135
No deficiency
21-64
Mild
1-20
Moderately severe
< 1
Severe

*Adult levels

References:

  1. Goldenberg N, Manco-Johnson M. Protein C deficiency. Haemophilia. 2008;14(6):1214–1221.

  2. Chalmers E, et al. Purpura fulminans: recognition, diagnosis and management. Archives of Disease in Childhood. 2011;96(11):1066-1071.

  3. Marlar RA, et al. Report on the diagnosis and treatment of homozygous protein C deficiency. Report of the Working Party on Homozygous Protein C Deficiency of the ICTH-Subcommittee on Protein C and Protein S. Thromb Haemost. 1989;61(3):529-31.

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